Phospho- RIPK2 (Ser176) Antibody - 100µg

Phospho-RIPK2 (Ser176) Antibody specifically detects the serine 176-phosphorylated form of Receptor-Interacting Serine/Threonine-Protein Kinase 2 (RIPK2), a ~61 kDa cytoplasmic kinase critical for innate immune signaling. Phosphorylation at Ser176 within the activation loop of RIPK2 is a key regulatory event that promotes its catalytic activity and oligomerization, facilitating downstream activation of NF-κB and MAPK pathways in response to NOD1/NOD2-mediated recognition of bacterial peptidoglycans. This site-specific antibody enables precise detection of RIPK2 activation status under inflammatory or infectious conditions and is validated for use in Western blot, immunoprecipitation, and immunofluorescence. It is widely employed in studies of host-pathogen interactions, inflammatory disease mechanisms, and therapeutic inhibition of NOD-RIPK2 signaling.