Phospho- Dab1 (Tyr232) Antibody - 100µg

Phospho-Dab1 (Tyr232) refers to the phosphorylated form of Disabled-1 (Dab1), an intracellular adaptor protein critically involved in the Reelin signaling pathway, at the tyrosine residue 232. Phosphorylation at Tyr232 is mediated predominantly by Src family kinases (SFKs) upon Reelin binding to its receptors, ApoER2 and VLDLR. This post-translational modification modulates Dab1’s interaction with SH2 domain-containing effectors, facilitating downstream signaling events essential for neuronal migration and cortical lamination during embryonic brain development. Phospho-Tyr232 serves as a site-specific marker for Reelin pathway activation and is tightly regulated spatiotemporally to ensure appropriate neurodevelopmental patterning.